Working in the heat: fixed-volume hydration may exceed water losses
In 20 adults, a fixed-volume hydration strategy prevented substantial body mass loss but produced a positive fluid balance.
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Recent studies and announcements, explained with the same rigor as our analyses: sources, context, and the limitations of the data.
The publication feed
Predicting jaw growth with AI: results still insufficient for clinical practice
A review of twelve studies examines AI-based prediction of craniofacial growth. Its superiority over conventional statistical methods remains to be established.
Cognition after stroke: findings on the BDNF Val66Met variant remain conflicting
A review of seven studies examines the link between a BDNF gene variant and cognition after stroke. The findings do not support individual prediction.
Hypertrophic cardiomyopathy: metabolic abnormalities, but no gene-specific signature
A review of 14 studies describes metabolic disturbances in hypertrophic cardiomyopathy without identifying a signature specific to genetic variants.
Stress and sleep: trial finds no clear advantage to combining two supplement blends
In 103 active adults, a morning blend shows some favorable signs after two weeks. Adding an evening blend provides no clear benefit.
MicroRNAs and neurological diseases: a promising review, but exclusively preclinical
A review of 37 studies explores microRNAs derived from mesenchymal stem cells in Parkinson’s, Alzheimer’s and stroke. No benefit in humans has been established.
Breast cancer: the cardioprotective effect of exercise during treatment remains uncertain
A review of seven randomized trials does not confirm that exercise preserves cardiac function during certain breast cancer treatments.
Periodontitis: coriander mouthwash has no detectable effect on the salivary microbiome
A small two-week trial compares coriander, chlorhexidine and water. The microbial findings do not establish a clinical benefit.
Mild cognitive impairment: a reduction in alcohol consumption observed after nutritional counseling
An analysis of BrainFit-Nutrition observes a reduction in alcohol consumption at 12 months in two nutritional counseling groups, without establishing a cognitive benefit.
Sleep after surgery: stellate ganglion block shows a benefit that remains uncertain
A meta-analysis of ten trials suggests better postoperative sleep, but the heterogeneity of the results limits confidence in this benefit.
Quercetin and medications: possible but still poorly characterized interactions
A systematic review examines interactions between quercetin and medications. The mechanisms are plausible, but human data remain limited.
Chickpea protein: altered biomarkers in cyclists, without evidence of better recovery
A small trial of a chickpea protein hydrolysate reports biochemical changes but measures neither recovery nor performance.
Athletes’ ECGs: inverted T waves are uncommon, but their risk remains uncertain
A meta-analysis estimates that inverted T waves occur in 4% of athletes over 16. Their significance requires evaluation.
Digital cognitive training: potential lasting benefits in older adults with mild impairment
A trial suggests sustained benefits after 20 hours of digital cognitive training, but their magnitude and the advantage over games remain unclear.
Creatine and football: review highlights benefits that remain uncertain
A review of 41 studies in football players reports mixed results and very low-certainty evidence, despite some favorable signals.
Bicarbonate: a modest boost during intense efforts in trained cyclists
A trial involving 24 cyclists reports increased power with bicarbonate, without demonstrating better long-term adaptations.
Creatine and resistance training: greater strength, without demonstrated fat loss
A meta-analysis of 63 studies suggests that adding creatine to resistance training improves strength and lean mass, but not fat mass.