Peanuts and the brain’s response to insulin: a localized signal in older adults
A small trial observes a change in the brain’s response to insulin after peanut consumption, without establishing a clinical benefit.
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Recent studies and announcements, explained with the same rigor as our analyses: sources, context, and the limitations of the data.
The publication feed
Dietary choline and cognition: a favorable association, not proof of protection
An observational meta-analysis links dietary choline to less cognitive impairment, without demonstrating that it prevents its onset.
Parkinson’s: genetic associations with depression, but no validated predictive test
An analysis of three studies links certain genetic profiles to depression in Parkinson’s. These exploratory findings do not demonstrate causality.
Autism: a review explores links between sensations, movement and body perception
A review of 37 studies links certain types of sensory processing to body representation in autism, without establishing causality or clinical applications.
Borderline personality disorder: no demonstrated additional clinical benefit from amygdala neurofeedback
A randomized pilot trial finds changes in amygdala activity, but no additional clinical benefit compared with intensive psychotherapy alone.
Oxaliplatin-associated neuropathy: a blood marker unrelated to symptoms in an exploratory study
In 30 patients receiving chemotherapy, blood pNF-H was not associated with the onset, severity or persistence of neuropathy.
Psychosis and cognition: the link with cortisol may depend on measurement time
A meta-analysis finds no overall link between basal cortisol and cognition in psychotic disorders, but identifies a specific signal late in the day.
GLP-1 and reward: a review of 66 animal studies points to a research avenue, without clinical evidence
A preclinical review finds reduced reward-related behaviors with GLP-1, without demonstrating psychiatric benefits in humans.
Autism: metallothioneins are not a validated biomarker
A systematic review of human studies finds no consistent alteration in metallothioneins associated with autism.
ADHD in children: promising digital interventions, but varying effects
A meta-analysis of 37 randomized trials suggests benefits for symptoms and cognition, without establishing their practical magnitude.
MRI and cognition: markers associated with cognitive impairment in small vessel disease
A review of 15 studies links white matter abnormalities to poorer cognitive performance, without establishing their reliability for early screening.
Anesthesia and back surgery: a planned trial on cerebral oxygenation in older patients
A protocol plans to compare remimazolam with propofol during spine surgery in the prone position. No results have been reported yet.
Preterm infants: a synbiotic alters the microbiota, but its brain benefits remain unproven
A secondary analysis of a trial links microbiota functions to brain maturation in preterm infants, without demonstrating a neurological benefit.
Exercise and mild cognitive impairment: possible benefits, but no established optimal dose
A meta-analysis links exercise to increased peripheral BDNF and improved depressive symptoms, without establishing an optimal dose.
Congenital heart disease: a trial will evaluate home-based physical and cognitive rehabilitation
QUALINEURO-REHAB will evaluate a programme combining physical activity and cognitive training in people aged 8–25. No efficacy results have been presented yet.
Neuropathic pain: exosomes remain a largely preclinical research avenue
A systematic review brings together 17 studies on stem cell-derived exosomes. The findings are largely preclinical and do not demonstrate efficacy in humans.
ADHD in children: lower ferritin, with no evidence of a benefit from iron
A meta-analysis links ADHD in children to lower ferritin. It demonstrates neither causality nor the effectiveness of supplementation.
Dementia in care facilities: virtual reality performs no better than cognitive stimulation in a trial
A trial involving 56 residents shows no greater benefit from virtual reality for behavioral symptoms or well-being.
Contact sports: biomarkers increase without establishing brain injury
A meta-analysis finds an increase in blood biomarkers after certain contact sports, but biases prevent conclusions about brain integrity.
Acupuncture and cognition: a short-term signal, with no evidence of lasting benefit
A meta-analysis of nine trials reports improvements on cognitive tests but demonstrates neither a lasting effect nor a slowing of the disease.