Parkinson’s: genetic associations with depression, but no validated predictive test
An analysis of three studies links certain genetic profiles to depression in Parkinson’s. These exploratory findings do not demonstrate causality.
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Recent studies and announcements, explained with the same rigor as our analyses: sources, context, and the limitations of the data.
The publication feed
Autism: a review explores links between sensations, movement and body perception
A review of 37 studies links certain types of sensory processing to body representation in autism, without establishing causality or clinical applications.
Borderline personality disorder: no demonstrated additional clinical benefit from amygdala neurofeedback
A randomized pilot trial finds changes in amygdala activity, but no additional clinical benefit compared with intensive psychotherapy alone.
Psychosis and cognition: the link with cortisol may depend on measurement time
A meta-analysis finds no overall link between basal cortisol and cognition in psychotic disorders, but identifies a specific signal late in the day.
GLP-1 and reward: a review of 66 animal studies points to a research avenue, without clinical evidence
A preclinical review finds reduced reward-related behaviors with GLP-1, without demonstrating psychiatric benefits in humans.
Autism: metallothioneins are not a validated biomarker
A systematic review of human studies finds no consistent alteration in metallothioneins associated with autism.
Acupuncture and cognition: a short-term signal, with no evidence of lasting benefit
A meta-analysis of nine trials reports improvements on cognitive tests but demonstrates neither a lasting effect nor a slowing of the disease.
Cognition after stroke: findings on the BDNF Val66Met variant remain conflicting
A review of seven studies examines the link between a BDNF gene variant and cognition after stroke. The findings do not support individual prediction.